| Process Application | Implementation |
| Buffer Preparation & Media Preparation |
Bulk solution preparation of: media, reagents, buffers and processing liquids. |
| Bag assemblies designed to offer filtration, storage, dispensing and sampling functionality. |
| Fermenter Sampling |
Sterile interfacing of sample bag assemblies with fermenter technology providing economical method for sample extraction. |
| Fermenter Additions |
Nutrient and anti-foam additions in fed-batch and perfusion applications. |
| Cell culture and seed culture inoculation of bioreactors via sterile interfacing technology. |
| Fermenter Harvesting |
Sterile or aseptic interfacing with fermenter for collection and storage of harvest material. |
| Single Use Perfusion Systems |
Single use hollow fiber perfusion system, including sterile bags for collection and storage of perfused material. |
| Single use perfusion system connection options for stainless steel and disposable bioreactors. |
| Single Use Tangential Flow Filtration Systems |
Integrated hollow fiber tangential flow filtration system for micro and ultra filtration. |
| Mixing and pressure monitoring functionality. |
Sterile bag:
- Process Reservoirs
- Permeate collection
- Buffer addition (diafiltration)
|
| Filtration | Normal flow micro filtration and intermediate storage of product using integrated filter-bag assemblies. |
| Polishing |
Intermediate product storage. |
| Delivery of buffer volumes for chromatography and TFF via robust bag assemblies. |
| Chromatography fraction and waste collection and storage. |
| Product Formulation and Dispensing |
Sterile filtration assemblies with built in sampling & integrity testing functionality. |
| Bulk product formulation & dispensing. |
| Shipping of final product bulk and aliquots. |
| Product Sampling |
Sterile product sampling assemblies:
- Integrated into process assemblies
- Connected to existing vessels via a sterile or aseptic interface.
|
| Waste Collection |
Process waste collection. |
| Isolator waste bags. |
